What does hyperplasia of goblet cells in chronic bronchitis lead to?

Hyperplasia of goblet cells in chronic bronchitis leads to excess mucus production. Goblet cells are responsible for the secretion of mucus in the respiratory tract, and when they undergo hyperplasia, there is an increase in their number. This results in a higher volume of mucus being produced in the airways.

In chronic bronchitis, which is often associated with long-term irritants such as tobacco smoke or pollution, the increased number of goblet cells contributes to a thickened mucus layer. This excess mucus can obstruct airways, impairing airflow and leading to various respiratory symptoms, including coughing and wheezing.

Understanding the role of goblet cells and their hyperplasia is crucial in recognizing the pathological changes in the airways during chronic bronchitis and how these changes relate to the clinical manifestations of the disease.