Which of the following could be a symptom of lung cancer aside from coughing up blood?

Hoarseness and loss of voice can indeed be symptoms associated with lung cancer. This occurs because lung tumors can affect the nearby structures, including the recurrent laryngeal nerve, which innervates the vocal cords. When the function of this nerve is disrupted due to tumor growth or pressure, it can lead to changes in voice, including hoarseness or loss of voice entirely. This is a significant symptom, as it may indicate the presence of malignancy in the thoracic region, particularly if it arises suddenly in individuals who are not typically prone to voice changes.

Other options, while they may be associated with various illnesses or conditions, are less indicative of lung cancer. For instance, fever and chills are more commonly linked to infections rather than tumors, and while wheezing and coughing can be seen in lung cancer, those symptoms are more general and not exclusive to malignant conditions. Rapid weight gain is typically not associated with lung cancer; rather, weight loss is more commonly reported as patients experience cachexia or other metabolic changes due to the malignancy.